Rejing UPT Upconversion Luminescence Technology--The World's First Commercialized UPT Technology and the Only One in China to Receive the National Technology Invention Award

In the field of Point of Care Testing (POCT) and on-site rapid diagnostics, traditional fluorescence detection methods often face limitations such as background interference, photobleaching, and insufficient sensitivity. Hotgen has introduced a breakthrough solution through its Upconversion Phosphor Technology (UPT) analyzer, particularly the UPT2800 model. This advanced UPT device represents the new generation of POCT testing platforms, capable of achieving a higher signal-to-noise ratio, exceptional stability, and quantitative detection results within minutes.
Combined with illustrated positioning, the Hotgen UPT-POCT platform boasts technical highlights such as the "world's first commercialized and the only UPT technology in China to receive the National Technological Invention Award," and supports Room Temperature Storage & Transport, making it more suitable for decentralized and on-site testing scenarios.

As Hotgen's flagship POCT testing platform, the UPT2800 combines advanced upconversion technology with rapid quantitative detection capabilities, specifically designed for decentralized and on-site testing applications.

As a compact and easy-to-use POCT system, the Hotgen UPT analyzer has been widely used in clinical laboratories, emergency departments, food safety testing, customs screening, and public health institutions. It combines rare earth nanoparticle technology with the principle of lateral flow immunoassay, effectively overcoming the shortcomings of traditional colloidal gold and ordinary fluorescence detection methods.

Analysis of Upconversion Phosphor Technology (UPT)

Upconversion Phosphor Technology is an advanced fluorescence labeling system based on rare earth-doped nanocrystals. Unlike traditional "downconversion" fluorescent dyes that excite with short wavelengths and emit long wavelengths, UPT particles adopt the opposite mechanism: absorbing infrared (near-infrared) light and emitting visible light, a process known as "photon upconversion."

This unique mechanism brings several core advantages:

• Extremely low background noise, as biological samples and most materials produce almost no autofluorescence under infrared excitation

• Virtually no photobleaching or fluorescence quenching, ensuring stable and repeatable signals

• High sensitivity, with detection capabilities typically superior to colloidal gold rapid tests

• Excellent anti-interference ability for complex sample matrices

Hotgen has successfully integrated this technology into practical diagnostic tools, enabling quantitative POCT testing even in resource-limited settings.
The UPT platform demonstrates Hotgen's innovative capabilities in high-sensitivity fluorescence POCT technology, achieving more stable and interference-resistant rapid quantitative detection.

Core Features of the Hotgen UPT2800 Analyzer

The UPT2800 is a representative product of the Hotgen UPT series, designed for ease of operation, portability, and versatility. Its compact size (355 mm × 315 mm × 270 mm) and lightweight design of only 5.6 kg allow it to easily adapt to laboratory benches or mobile testing stations.

Key configurations include:

• 8-inch high-resolution touchscreen for intuitive and convenient operation

• Results available in just 20 seconds after inserting the test strip

• Built-in thermal printer for immediate report printing

• Storage capacity for up to 10,000 test results

• Support for multiple languages (English, German, Chinese)

• Support for LIS/HIS connectivity for seamless integration with laboratory systems

• Adaptability to a wide operating environment (10℃~30℃, humidity ≤85%)

The analyzer is used in conjunction with Hotgen's proprietary UPT lateral flow test strips. Users only need to add the sample, wait for incubation (usually 10-15 minutes), and insert the test strip into the device to quickly obtain accurate quantitative results. The entire process requires almost no complex training, making it very suitable for primary healthcare institutions, emergency response teams, and on-site testing applications.
Its portable design and rapid testing process make the UPT2800 particularly suitable for decentralized diagnostics, mobile testing, and emergency response scenarios.

Extensive Clinical and Industry Applications

The Hotgen UPT analyzer supports a variety of test reagents to meet the needs of different fields:

Clinical Diagnostics
The system performs excellently in the rapid detection of cardiac markers, inflammation indicators (such as CRP and SAA), rheumatoid arthritis markers, liver function indicators, diabetes-related markers, sex hormones, kidney injury indicators, and preterm prediction markers. Its high sensitivity and quantitative detection capabilities make it particularly important in emergency chest pain evaluation, infection screening, chronic disease management, and maternal and child health monitoring.

Food Safety and Mycotoxin Detection
In the food industry, the UPT2800 can be used for the quantitative detection of major mycotoxins (such as aflatoxins and ochratoxins) in grains, feeds, and agricultural products. Its rapid and accurate characteristics help regulatory agencies and production enterprises efficiently maintain strict quality control standards.

Drug Screening and Security Applications
Hotgen UPT technology can also be applied to drug abuse detection in hair, saliva, and urine samples. The system's high sensitivity and tamper-proof characteristics make it very suitable for customs, detox centers, workplace screening, and border control scenarios.

Infectious Disease Management
The platform performs excellently in the detection of various pathogens and inflammatory responses, supporting rapid response during outbreaks and routine monitoring work.

The wide range of applications of the UPT platform fully demonstrates its multifunctional value in clinical diagnostics, public health, food safety, and security screening.

Core Advantages Compared to Traditional Methods

Compared to colloidal gold rapid testing, Hotgen UPT technology can provide true quantitative results, not just simple positive or negative interpretations. Compared to chemiluminescence or ELISA methods, it can achieve faster detection speeds without requiring complex laboratory infrastructure or highly specialized personnel; at the same time, reagents support room temperature storage and transportation, further reducing deployment and supply chain barriers.

Core advantages include:

• High sensitivity and specificity with excellent signal stability

• Strong matrix anti-interference ability, suitable for whole blood, serum, plasma, urine, saliva, and even tissue homogenate samples

• Accurate quantitative capability to support clinical decision-making

• Portable and easy to operate, truly achieving POCT deployment

• Long shelf life of reagents and low equipment maintenance costs, offering good economic value

The robust and durable design of the UPT2800 ensures stable operation under various environmental conditions, whether in urban hospitals, remote rural clinics, or mobile testing vehicles.
By combining quantitative fluorescence detection with POCT convenience, the UPT2800 achieves an ideal balance between laboratory-grade performance and on-site application capability.

User-Friendly Operation and Data Management

The Hotgen UPT analyzer is easy to operate. After simple training, operators can easily complete tests through the large screen. The system can automatically perform quality checks, calculate concentrations based on built-in calibration curves, and print or export results.

Advanced data management functions allow laboratories to track trends, generate statistical reports, and integrate results into hospital information systems. This connectivity capability is especially important for large-scale screening projects and public health monitoring networks.
Its intelligent software and integrated data management capabilities further enhance workflow efficiency and result traceability.

Hotgen's Innovation in POCT Technology

Hotgen positions the UPT platform as a core component of its multi-technology diagnostic product system. By simultaneously developing the UPT2800 analyzer and complete supporting reagents, the company has achieved overall performance optimization and quality consistency from equipment to reagents. This vertical integration strategy has earned the platform widespread recognition in the medical, food safety, and security fields.

The technology has received multiple certifications and is continuously expanding in domestic and international markets. Its application in public health emergencies further proves its reliability and practical application value.
As one of Hotgen's important innovative POCT platforms, the UPT system demonstrates the company's strength in continuously advancing innovation in rapid quantitative diagnostic technology.

Why Choose the Hotgen UPT Analyzer

For laboratories and institutions seeking a balance of performance, simplicity, and economy, the Hotgen UPT2800 is the ideal choice. Whether in rapid cardiac assessment in the emergency room, on-site food safety testing, or large-scale infectious disease screening, this UPT device can quickly and stably provide reliable quantitative data.

Its compact size, low maintenance requirements, and rich testing menu make it particularly suitable for:

• Primary healthcare and community health centers

• Emergency and mobile medical units

• Food and drug regulatory agencies

• Customs and border control agencies

• Veterinary and agricultural testing laboratories

Conclusion: A Powerful Tool for Modern Rapid Diagnostics

The Hotgen Upconversion Phosphor Technology (UPT) analyzer, represented by the UPT2800, marks a significant advancement in the field of POCT fluorescence detection. By utilizing the unique properties of upconversion phosphor particles, this system achieves high sensitivity, excellent stability, and true quantitative detection capability in a compact and easy-to-use device, supporting room temperature storage and transport, further enhancing the accessibility and implementation efficiency of POCT.

As Hotgen's flagship upconversion phosphor POCT platform, the UPT2800 demonstrates the company's innovative strength in rapid quantitative fluorescence diagnostics and decentralized testing solutions.
For more information on the Hotgen UPT analyzer and its complete testing reagent menu, visit the Hotgen official website to further explore how this advanced UPT device can enhance your testing capabilities.